Margaret Fleming Selected Research

1- (((2S,3S,4S)- 3- ethyl- 4- fluoro- 5- oxopyrrolidin- 2- yl)methoxy)- 7- methoxyisoquinoline- 6- carboxamide

12/2021

The Interleukin-1 Receptor-Associated Kinase 4 Inhibitor PF-06650833 Blocks Inflammation in Preclinical Models of Rheumatic Disease and in Humans Enrolled in a Randomized Clinical Trial.

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Margaret Fleming Research Topics

Disease

4	Inflammation (Inflammations) 12/2021 - 04/2006
4	Asthma (Bronchial Asthma) 07/2010 - 04/2006
3	Chronic Obstructive Pulmonary Disease (COPD) 11/2019 - 07/2010
1	Systemic Lupus Erythematosus (Libman-Sacks Disease) 12/2021
1	Rheumatic Diseases (Rheumatism) 12/2021
1	Experimental Arthritis 12/2021
1	Rheumatoid Arthritis 12/2021
1	Obstructive Lung Diseases (Obstructive Lung Disease) 11/2019
1	Bacterial Infections (Bacterial Infection) 11/2017
1	Autoimmune Diseases (Autoimmune Disease) 11/2017
1	Colorectal Neoplasms (Colorectal Cancer) 08/2017
1	Osteoporosis 08/2017
1	Acute Kidney Injury (Acute Renal Failure) 01/2016
1	Diabetic Nephropathies (Diabetic Nephropathy) 01/2016
1	Kidney Diseases (Kidney Disease) 01/2016
1	Proteinuria 01/2016
1	Reperfusion Injury 01/2016
1	Chronic Renal Insufficiency 01/2016
1	Pneumonia (Pneumonitis) 01/2012
1	Emphysema 08/2010
1	Lung Diseases (Lung Disease) 08/2010
1	Respiratory Hypersensitivity 04/2006

Drug/Important Bio-Agent (IBA)

3	ChitinasesIBA 03/2010 - 04/2006
2	Interleukin-1 Receptor-Associated KinasesIBA 12/2021 - 11/2017
2	Phosphotransferases (Kinase)IBA 12/2021 - 11/2017
2	LigandsIBA 12/2021 - 11/2017
2	Toll-Like Receptors (Toll-Like Receptor)IBA 12/2021 - 11/2017
2	Biomarkers (Surrogate Marker)IBA 01/2016 - 08/2010
2	Proteins (Proteins, Gene)FDA Link 01/2016 - 04/2006
1	Antigen-Antibody Complex (Immune Complex)IBA 12/2021
1	pristane (pristan)IBA 12/2021
1	Anti-Citrullinated Protein AntibodiesIBA 12/2021
1	1- (((2S,3S,4S)- 3- ethyl- 4- fluoro- 5- oxopyrrolidin- 2- yl)methoxy)- 7- methoxyisoquinoline- 6- carboxamideIBA 12/2021
1	GoldIBA 11/2019
1	Transcription Factors (Transcription Factor)IBA 11/2017
1	Interferon Regulatory FactorsIBA 11/2017
1	Prostate-Specific Antigen (Semenogelase)IBA 08/2017
1	Influenza Vaccines (Influenza Vaccine)FDA Link 08/2017
1	Cytokine TWEAKIBA 01/2016
1	TWEAK ReceptorIBA 01/2016
1	Folic Acid (Vitamin M)FDA LinkGeneric 01/2016
1	Messenger RNA (mRNA)IBA 01/2016
1	AllergensIBA 01/2012
1	ElastinIBA 08/2010
1	Pancreatic Elastase (Elastase)IBA 08/2010
1	Peptide Hydrolases (Proteases)FDA Link 08/2010
1	Serine (L-Serine)FDA Link 07/2010
1	Matrix Metalloproteinases (MMPs)IBA 07/2010
1	EnzymesIBA 03/2010
1	ChitinIBA 03/2010
1	HydrolasesIBA 04/2006
1	CytokinesIBA 04/2006

Therapy/Procedure

1	Therapeutics 03/2009